beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

A novel mutation in the TATA box in a Japanese patient with beta +-thalassemia.

A single base substitution (A-G) at position -31 within the highly conserved proximal promoter element, the TATA box, was identified in the beta-globin gene cloned from a Japanese woman with beta +-thalassemia. It appears that she is homozygous for this specific allele, as determined by haplotype analysis using seven different polymorphic sites in the beta-globin gene cluster. Transient express...

THE SPECTRUM OF BETA – THALASSEMIA MUTATIONS IN IRAN

Frequencies of thalassemia in American blacks.

The frequency of thalassemia was determined in a group of 541 healthy adult black males. Individuals with decreased mean corpuscular hemoglobin (MCH) values were evaluated further with hemoglobin analysis, iron studies, and globin chain synthesis. Of the males screened, 13.4% had MCH levels below 27.0 pg, while 1.4% had heterozygous beta thalassemia, 2.3% had iron deficiency, and 5.7% had globi...

A Novel Mutation in the TATA Box in a Japanese Patient With fl-Thalassemia

A single base substitution (A-G) at position 31 within the highly conserved proximal promoter element. the TATA box, was identified in the fi-globin gene cloned from a Japanese woman with fl -thalassemia. It appears that she is homozygous for this specific allele, as determined by haplotype analysis using seven different polymorphic sites in the fl-globin gene cluster. Transient expression of the

the american dream in three plays by eugene oneill, tennessee williams, and lorraine hansberry

این مطالعه به نقد و بررسی مفهوم اسطوره ی رویای امریکایی در سه نمایشنامه ی قرن بیستم امریکایی می پردازد، که این نمایشنامه ها عبارتند از: the iceman cometh (مرد یخین می آید) نوشته ی یوجین اونیل، 1940؛ desirea streetcar named (اتوبوسی به نام هوس) نوشته ی تنسی ویلیامز، 1947؛ و in the sun raisin a (انگور خشکیده در آفتاب) ، نوشته ی لورین هنزبری، 1958. هدف از این بررسی، ابتدا شناخت مفهوم رویای امری...